The role of manganese in human disease.
نویسنده
چکیده
The role of manganese in the human body as well as its toxic effects as a potent neurotoxic metal are discussed. At present, emphasis is being placed on the study of susceptibility to manganese poisoning because manganese is a potential atmospheric pollutant, if lead in gasoline is to be replaced by Mn. Mn is a potent antiknock agent. Anemic individuals who show increased iron and manganese intestinal absorption and newborns might be among the sus ceptible populations.
منابع مشابه
Manganese and Iron Binding to Human Transferrin
The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manganese (1.5 µg/ml) to the reaction mixture contai...
متن کاملManganese and Iron Binding to Human Transferrin
The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manganese (1.5 µg/ml) to the reaction mixture contai...
متن کاملManganese: A Potent Antioxidant in Semen
Antioxidant are the agents which dispose / scavenge the reactive oxygen species, minimize the oxidative stress / lipid peroxidation and ultimately improve the fertilizing potential of the spermatozoa. Currently, many antioxidants are under investigation and manganese is one of them in reducing the oxidative stress both in male and female. The antioxidative action of manganese (Mn2+) on various ...
متن کاملPrevention of Nonalcoholic Steatohepatitis in Rats by Two Manganese-Salen Complexes
Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation. Investigations have suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. To provide further insights into beneficial effects of antioxidants in NASH prevention, we employed two manganese-supero...
متن کاملPossible role for integrins in the development of tolerance to the analgesic effect of morphine in male rats
There is some evidence supporting the reduced activity of integrins following chronic administration of morphine. This reduction might play a role in morphine tolerance development. Manganese binds to the extracellular domain of integrins and makes them to be activated. The effect of integrins activation using manganese on tolerance development to the analgesic effect of morphine was investi...
متن کاملDesign, Synthesis and Antitubercular Evaluation of Novel Series of Pyrazinecarboxamide Metal Complexes
The interest in the synthesis of metallic complexes of different drugs to make them moreefficient in biological environment of the human body is seen for the last few decades. Widerange of metal complexes are already used in clinical practice which encourages additionalresearch for innovating new metal based drugs, such as metal-mediated antibiotics, antiparasitic,antiviral, antibacterial, and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Annals of clinical and laboratory science
دوره 4 6 شماره
صفحات -
تاریخ انتشار 1974